IRF1 deficiency predisposes cartilage to accumulate DNA damage and promotes osteoarthritis development

Interferon regulatory factor 1 (IRF1) is a transcriptional regulator conventionally associated with immunomodulation. Recent molecular analyses mapping DNA binding sites of IRF1 have suggested its potential function in DNA repair. However, the physiological significance of this non-canonical function remains unexplored. Here, we investigated IRF1's role in osteoarthritis (OA), a condition marked by senescence and chronic joint inflammation.

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